From Tetanus to Whooping Cough: The Triple Protection of Tdap

When you go in for a check-up and hear your healthcare provider recommend a Tdap booster, you might be thinking: What is Tdap, anyway? 

The Tdap vaccine protects against three serious bacterial diseases– tetanus, diphtheria, and pertussis (whooping cough). While many people think of vaccines as something only for infants, the Tdap vaccine provides important protection for adolescents and adults too. This issue is very pressing, with Louisiana currently experiencing one of the worst recent outbreaks of whooping cough. Let’s break down what makes this specific vaccine so important.

Background on Tdap

Vaccines for diphtheria and tetanus became available in the 1920s and 1930s, with Gaston Ramon, a French veterinarian and biologist, developing diphtheria toxoid in 1923. Fifteen years later, an effective adsorbed tetanus toxoid was created in 1938 leading to the combined DTP vaccine in the 1940s. Later, protection against pertussis was added. Today’s Tdap vaccine combines all three into one shot, making it simple to stay protected. 

The “T” – Tetanus 

Tetanus is caused by Clostridium tetani, a toxin-producing bacterium found in soil, dust, saliva, and manure. People can get tetanus when bacteria enter the body through a puncture wound or cut. If you accidentally scrape yourself and are exposed to any of the above sources (soil, dust, saliva, or manure), your primary care doctor may suggest you receive a Tdap booster if you are not up to date. Devastatingly, tetanus still causes around 50,000 deaths worldwide annually, and can specifically affect regions where vaccination rates are low, such as in developing countries. This emphasizes why staying up to date with boosters is extremely important to staying healthy.

Tetanus attacks the nervous system, causing:

  • Severe muscle spasms in the jaw (“lockjaw”)
  • Painful stiffness in the neck, abdomen, and back
  • Difficulty swallowing and breathing

Tetanus is not contagious, but it’s life-threatening. Unlike many infections, once you have it, your body doesn’t build lasting immunity. That’s why regular vaccination is the only reliable protection.

The “D” – Diptheria

Diphtheria is caused by Corynebacterium diphtheriae, a bacterial infection that spreads from person to person through respiratory droplets. Before the vaccine was introduced in the 1940’s, an estimate of 100,000 to 200,000 diphtheria cases and 13,000 to 15,000 deaths occurred every year in the United States. Now, due to modern medicine, better healthcare systems, and increased vaccinations, Diphtheria has a rate of 5-10% fatality. In 2013, there were 3,000 deaths worldwide for Diphtheria, compared to 8,300 deaths in 1990. 

Diphtheria primarily affects the respiratory system, leading to:

  • Severe sore throat
  • Thick gray coating in the throat and nose
    Breathing difficulties
  • Heart and nerve damage in severe cases

Thanks to widespread vaccination, diphtheria is now extremely rare in the U.S., but it still circulates in other parts of the world, primarily affecting newborns, children, and older adults.

The “p”: Pertussis (Whooping Cough)

Pertussis, commonly known as whooping cough, is a highly contagious respiratory illness. It spreads quickly in schools, households, and communities, and can be especially dangerous for babies who are too young to be fully vaccinated.

Symptoms include:

  • Intense coughing fits that can last for weeks
  • The signature “whoop” sound during breathing
  • Vomiting or exhaustion after coughing

While older children and adults can recover, infants are at the highest risk for severe illness, hospitalization, and even death. While Diphtheria and Tetanus are relatively rare in the U.S., Pertussis still is present and threatens vulnerable babies. The current whopping cough outbreak occurring in Louisiana has been ongoing for the past year. Typically, the state has averaged 77 cases a year in the past 21 years, and officials have reported 368 cases of the illness this year to date. Additionally, it was found that 75% of those who were hospitalized for Pertussis in Louisiana were either not vaccinated or not up to date on their boosters for the disease. 

Vaccines Prevent Disease

Immunity from childhood vaccines doesn’t last forever. That’s why the CDC recommends a Tdap booster at ages 11–12. Adults should also get at least one Tdap dose if they haven’t already, and pregnant people are advised to get it during each pregnancy to help protect newborns. Boosters refresh waning immunity, prevent outbreaks in schools and communities, and reduce the risk of carrying bacteria to infants and those with weakened immune systems

When vaccination rates decline, diseases can come roaring back. For example, in early 2005, a pertussis outbreak occurred in an Amish Community in Kent County, Delaware, resulting in 345 cases. While the Amish community does not prohibit vaccination, coverage for childhood vaccines is low in many Amish communities. That same year, an outbreak of pertussis in California led to at least seven deaths. Many people think of whooping cough as a disease that disappeared in the 1940s when the vaccine became available, but it has been slowly on the rise because of waning immunity. Earlier this year, the CDC reported that Pertussis cases were trending up two-fold from 2024.

Another example of the power of vaccines to eradicate disease is the polio vaccine. The polio vaccine was licensed in 1955. Before the polio vaccine, there had been several polio outbreaks in the U.S. and was a significant cause of disability in children. Thanks to widespread vaccination, polio was considered eliminated in North America by 1994.  These examples remind us that vaccines don’t just protect individuals, they safeguard entire communities.

The Bottom Line: Protecting Yourself and Others

The Tdap vaccine is more than just another shot. It’s a powerful shield against three dangerous diseases. By staying up to date with recommended boosters, you’re not only protecting yourself, you’re also helping protect infants, grandparents, and anyone with a weaker immune system. So the next time your doctor reminds you about a Tdap booster, you’ll know exactly how important this vaccine is.

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Hope Durlofsky

Hope Durlofsky

Hope is an Outreach and Development Intern at Unity Consortium. She is also an MPH candidate, with a focus in Population & Family Health and Infectious Disease Epidemiology.

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